References [1] Santhosh Kumar MP. Local hemostatic agents in the management of bleeding in oral surgery. Asian Journal of Pharmaceutical and Clinical Research. 2016;9:3.
[2] Qerimi B, Baumann P, Husing J, Knaebel HP, Schumacher H. Collagen hemostat significantly reduces time to hemostasis compared with cellulose: COBBANA, a single-center, randomized trial. Am J Surg. 2013;205(6):636-41.
[3] Fontana T, Silvestri V, Falco N, Venturelli P, Licari L, De Marco P, Gulotta E, Gulotta L, Cocorullo G. Fibrin sealant agents: clinical application of Tachosil® in abdominal surgery. Six years
experience in an emergency surgery department and review of the literature. Il Giornale di chirurgia. 2018;39(5):326-330.
[4] [Data on file] Weber. Summary of animal studies to test three different hemostatic devices, which are used to stop severe liver bleeding (2006).
[5] [Data on file] Weber. Research program testing hemostatic compress material (Sangustop) in a functionality study (Hemostasis of severe liver bleedings) (2007).
[6] Chattopadhyay S, Raines RT. Review collagen-based biomaterials for wound healing. Biopolymers. 2014;101(8):821-33.
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